Denoise Undersampled Flow Phantom Data

The following compares divergence-free wavelet denoising with other methods on undersampled data reconstructed by ESPIRiT/SENSE with no regularization. Divergence-free wavelet with manually chosen thresholds is also compared

see demo_phantom.m for denoising performances on fully sampled data

Contents

Clear all and check path

close all
clc
clear

if ~exist('dfwavelet_thresh','file')
    error('Cannot find dfwavelet functions. run setPath!');
end

Load phantom data and set parameters

load 4dFlow_007


% Eddy Current Correction
calib = [127-100,128+100;127-40,128+40;32-20,32+20];
[vxEddy,vyEddy,vzEddy] = eddyCorr(vx,vy,vz,calib);
vx = vx-vxEddy;
vy = vy-vyEddy;
vz = vz-vzEddy;


% Crop to pipe for faster performance
% Comment the following to denoise the entire flow data
imMag = imMag(20:250,1:64,17:49);
vx = vx(20:250,1:64,17:49);
vy = vy(20:250,1:64,17:49);
vz = vz(20:250,1:64,17:49);
vxEddy = vxEddy(20:250,1:64,17:49);
vyEddy = vyEddy(20:250,1:64,17:49);
vzEddy = vzEddy(20:250,1:64,17:49);


% Set parameters
imThresh = 7000;                % Image threshold for segmentation
imMask = (imMag>imThresh)*1;    % Segmentation mask
vMag = getVelMag(vx,vy,vz);     % Velocity magnitude
vMax = 1.0127e+03;              % Maximum speed
FOV = size(vMag);               % Field of view
N = FOV(3);                     % Number of slices (for plotting)
ph0 = zeros(FOV);               % Reference phase in phase contrast


% Plot
figure,imshow_flow(imMask,vx,vy,vz,vMax,[1,2,3]),title('Original Flow Field','FontSize',14);
figure,imshow_flowmag(imMask,vx,vy,vz,vMax,[1,2,3]),title('Original Velocity Magnitude','FontSize',14);
pause(1);

Load Reconstructed Flow from undersampled data

load 4dFlow_007_subsample


% Crop to pipe for faster performance
% Comment the following to denoise the entire flow data
vxN = vxN(20:250,1:64,17:49);
vyN = vyN(20:250,1:64,17:49);
vzN = vzN(20:250,1:64,17:49);


% Eddy Current Correction
vxN = vxN-vxEddy;
vyN = vyN-vyEddy;
vzN = vzN-vzEddy;


% Mask flow data with good segmentation
[vxN,vyN,vzN] = maskIM(imMask,vxN,vyN,vzN);


% Plot
figure,imshow_flow(imMask,vxN,vyN,vzN,vMax,[1,2,3]),title('Reconstructed Flow Field','FontSize',14);
figure,imshow_flowmag(imMask,vxN,vyN,vzN,vMax,[1,2,3]),title('Reconstructed Velocity Magnitude','FontSize',14);


% Calculate errors
disp('Reconstructed Flow Error')
[vNRMSE_Noise,vMagErr_Noise,angErr_Noise] = calcVelError(imMask,vx,vy,vz,vxN,vyN,vzN);
PVNR = 20*log10(1/vNRMSE_Noise);
fprintf('PVNR: \t\t\t%.2fdB\nNRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',PVNR,vNRMSE_Noise,vMagErr_Noise,angErr_Noise);

pause(1)
Reconstructed Flow Error
PVNR: 			29.47dB
NRMSE: 			0.033631
vMag Error: 		0.019393
Absolute Angle Error: 	0.024910

DivFree Wavelet with SureShrink and MAD sigma estimation

Here, we use Median Absolute Deviation to estimate noise std and then use SureShrink to find the optimal threshold that minimizes MSE

minSize = 8*ones(1,3); % Smallest wavelet level size

% Denoise
[vxDFWsm,vyDFWsm,vzDFWsm] = dfwavelet_thresh_SURE_MAD(vxN,vyN,vzN,minSize,res);


% Plot
figure,imshow_flow(imMask,vxDFWsm,vyDFWsm,vzDFWsm,vMax,[1,2,3])
title('Div Free Wavelet w/ SureShrink (Flow Field)','FontSize',14)
figure,imshow_flowmag(imMask,vxDFWsm,vyDFWsm,vzDFWsm,vMax,[1,2,3])
title('Div Free Wavelet w/ SureShrink (Vel Mag)','FontSize',14)


% Calculate errors
disp('DivFree Wavelet sureShrink w/ MAD')
[vNRMSE_DFWsm,vMagErr_DFWsm,angErr_DFWsm] = calcVelError(imMask,vx,vy,vz,vxDFWsm,vyDFWsm,vzDFWsm);
fprintf('NRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',vNRMSE_DFWsm,vMagErr_DFWsm,angErr_DFWsm);
pause(1);
DivFree Wavelet sureShrink w/ MAD
NRMSE: 			0.030420
vMag Error: 		0.017794
Absolute Angle Error: 	0.021827

DivFree Wavelet with SureShrink, MAD and random cycle spinning

To remove the blocking artifacts, we do partial cycle spinning Here we do 2^3=8 random shifts

spins = 2;              % Number of cycle spinning per dimension
isRandShift = 1;        % Use random shift
minSize = 8*ones(1,3);  % Smallest wavelet level size


% Denoise
[vxDFWsms,vyDFWsms,vzDFWsms] = dfwavelet_thresh_SURE_MAD_spin(vxN,vyN,vzN,minSize,res,spins,isRandShift);


% Plot
figure,imshow_flow(imMask,vxDFWsms,vyDFWsms,vzDFWsms,vMax,[1,2,3])
title('Div Free Wavelet w/ SureShrink and Partial Cycle Spinning (Flow Field)','FontSize',14)
figure,imshow_flowmag(imMask,vxDFWsms,vyDFWsms,vzDFWsms,vMax,[1,2,3])
title('Div Free Wavelet w/ SureShrink and Partial Cycle Spinning (Vel Mag)','FontSize',14)


% Calculate errors
disp('DivFree Wavelet w/ SureShrink, MAD and Partial Cycle Spinning')
[vNRMSE_DFWsms,vMagErr_DFWsms,angErr_DFWsms] = calcVelError(imMask,vx,vy,vz,vxDFWsms,vyDFWsms,vzDFWsms);
fprintf('NRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',vNRMSE_DFWsms,vMagErr_DFWsms,angErr_DFWsms);
pause(1);
DivFree Wavelet w/ SureShrink, MAD and Partial Cycle Spinning
NRMSE: 			0.029874
vMag Error: 		0.017450
Absolute Angle Error: 	0.021446

DivFree Wavelet with SureShrink and manually chosen thresholds

spins = 2;              % Number of cycle spinning per dimension
isRandShift = 1;        % Use random shift
minSize = 8*ones(1,3);  % Smallest wavelet level size
dfThresh = 15;          % Threshold for divfree component
nThresh = 20;           % Threshold for non-divfree component


% Denoise
[vxDFW,vyDFW,vzDFW] = dfwavelet_thresh_spin(vxN,vyN,vzN,minSize,res,dfThresh,nThresh,spins,isRandShift);


% Plot
figure,imshow_flow(imMask,vxDFW,vyDFW,vzDFW,vMax,[1,2,3]),
title('Div Free Wavelet w/ manual threshold and random cycle spinning (Flow Field)','FontSize',15)
figure,imshow_flowmag(imMask,vxDFW,vyDFW,vzDFW,vMax,[1,2,3]),
title('Div Free Wavelet w/ manual threshold and random cycle spinning (Vel Mag)','FontSize',15)


% Calculate errors
vMagDFW = getVelMag(vxDFW,vyDFW,vzDFW);
disp('DivFree Wavelet w/ Manual Thresh')
[vNRMSE_DFW,vMagErr_DFW,angErr_DFW] = calcVelError(imMask,vx,vy,vz,vxDFW,vyDFW,vzDFW);
fprintf('NRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',vNRMSE_DFW,vMagErr_DFW,angErr_DFW);
pause(1);
DivFree Wavelet w/ Manual Thresh
NRMSE: 			0.023951
vMag Error: 		0.015891
Absolute Angle Error: 	0.015785

Finite Difference Method

The following implements finite difference method denoising as described in: Song SM, Pelc NJ., et al. JMRI 1993 Noise reduction in three-dimensional phase-contrast MR velocity measurements.

% Denoise
[vxFDM,vyFDM,vzFDM] = fdmDenoise(vxN,vyN,vzN,res);


% Plot
figure,imshow_flow(imMask,vxFDM,vyFDM,vzFDM,vMax,[1,2,3])
title('Div Free FDM','FontSize',14)
figure,imshow_flowmag(imMask,vxFDM,vyFDM,vzFDM,vMax,[1,2,3])
title('Div Free FDM','FontSize',14)


% Calculate errors
disp('Finite Difference Method Error')
[vNRMSE_FDM,vMagErr_FDM,angErr_FDM] = calcVelError(imMask,vx,vy,vz,vxFDM,vyFDM,vzFDM);
fprintf('NRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',vNRMSE_FDM,vMagErr_FDM,angErr_FDM);
pause(1);
Finite Difference Method Error
NRMSE: 			0.038941
vMag Error: 		0.023989
Absolute Angle Error: 	0.029318

DivFree Radial Basis Function

The following implements divergence-free radial basis function denoising as described in: Busch J, Kozerke S., et al. MRM 2012 Construction of divergence-free velocity fields from cine 3D phase-contrast flow measurements.

radius = 4;     % Radius of kernel
nIter = 20;     % Number of iterations for lsqr

% Plot during iterations, if on, does gradient descent instead of lsqr
doplot = 0;

% Denoise
% Takes a while to run
[vxRBF,vyRBF,vzRBF] = rbfDenoise(vxN,vyN,vzN,imMask,radius,res,nIter,doplot);


% Plot
figure,imshow_flow(imMask,vxRBF,vyRBF,vzRBF,vMax,[1,2,3]),
title('Div Free RBF','FontSize',14)
figure,imshow_flowmag(imMask,vxRBF,vyRBF,vzRBF,vMax,[1,2,3]),
title('Div Free RBF','FontSize',14)


% Calculate errors
disp('Radial Basis Function Error')
[vNRMSE_RBF,vMagErr_RBF,angErr_RBF] = calcVelError(imMask,vx,vy,vz,vxRBF,vyRBF,vzRBF);
fprintf('NRMSE: \t\t\t%f\nvMag Error: \t\t%f\nAbsolute Angle Error: \t%f\n\n',vNRMSE_RBF,vMagErr_RBF,angErr_RBF);
pause(1);
RBF Denoising...
done
Radial Basis Function Error
NRMSE: 			0.023357
vMag Error: 		0.015485
Absolute Angle Error: 	0.015471

Plot all

Plotting results from all methods.

figure,imshow_flowmag(...
    cat(2,imMask,imMask,imMask,imMask,imMask,imMask),...
    cat(2,vx,vxN,vxDFWsms,vxDFW,vxFDM,vxRBF),...
    cat(2,vy,vyN,vyDFWsms,vyDFW,vyFDM,vyRBF),...
    cat(2,vz,vzN,vzDFWsms,vzDFW,vzFDM,vzRBF),...
    vMax,[1,2,3]);

title('Original,Noisy,DFW/spin,DFW/manual,FDM and RBF','FontSize',14)